CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Alteration in the immune response induced by exposure to chronic stress. Different sensitive of Balb/c and C57B/6 mice to noise and inmivilization stress
Autor/es:
PASCUAN CECILIA GABRIELA; URAN SOLEDAD L.; GONZALEZ-MURANO MARÍA ROSA; RUBINSTEIN MARA ROXANA; GUELMAN LAURA R; GENARO ANA MARÍA
Lugar:
Dresden
Reunión:
Congreso; 8th congress of the International Society for neuroImmunoModulation (ISNIM) together with the German Endocrine-Brain-Immune Network (GEBIN); 2011
Institución organizadora:
International Society for neuroImmunoModulation (ISNIM) y German Endocrine-Brain-Immune Network (GEBIN)
Resumen:
Noise is considered an environmental stressor that can alter the immune response, but whether the mechanisms involved are similar to other stressors is controversial. We have previously described that Balb/c mice are more sensitive to the deleterious effects of chronic mild stress than C57Bl/6 mice. The aim of this study was to investigate alterations in the immune response induced by exposure to noise (NS) (95?97dB, 1h/day) compared to the stress induced by immobilization (IS) (2 h per day) during 2 weeks in these strains (n = 6 for each group). We observed that Balb/c mice exposed to NS do not show alterations in either the proliferative response in vitro or antibody production in vivo. However, the C57Bl/6 mice showed a decrease in the proliferative response of T cells and in the production of IgG antibodies when they were immunized with sheep red blood cells. On the other hand, no significant differences were found in the proliferative response or the title of IgG antibodies in mice subjeted to IS. In addition, Balb/c mice exposed to NS showed a significant decrease in the levels of catecholamines and corticosterone. No significant differences in the levels of these hormones were found in the C57BL/6 mice exposed to NS and in both strains exposed to IS. These results indicate that the alterations induced by noise are different to other stressors, in which the involvement of catecholamines and corticosteroids could be different from the classically described