CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The exposure to an enriched environment prevents acute visual ischemic injury in adult rats
Autor/es:
DORFMAN D; FERNANDEZ DC; ROSENSTEIN RE
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; XXVI Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2011
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Retinal ischemia may provoke blindness. There is no effective treatment for retinal ischemic damage. Recent evidence supports that exposure of adult amblyopic rats to an enriched environment (EE) promotes full visual acuity recovery. We analysed the effect of exposure to an EE in an acute retinal ischemia model. Adult male Wistar rats were exposed to a standard environment (SE) or EE. EE consisted of big cages with food hoppers, wheels and different objects repositioned once/day and fully substituted once/week. After 3 weeks of exposure to SE or EE, unilateral ischemia was induced, and afterwards, animals were returned to their respective environment for 2 weeks. Retinal function (electroretinography, ERG) and histology, anterograde transport to the superior colliculus (SC) and glial reactivity in the SC (GFAP staining) were analysed. In control animals, ischemia induced a significant decrease in ERG a- and b- wave amplitude and retinal ganglion cell (RCG) loss, GFAP staining increase in the SC and a decline in anterograde transport. The exposure to an EE partially prevented retinal dysfunction, RCG loss and GFAP stain in the SC. Anterograde transport was fully preserved. These results suggest that the exposure to an EE could become a new strategy for retinal ischemia treatment.