CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
New perspectives in glaucoma: unrecognized symptoms and looking for new therapeutic strategies.
Autor/es:
ROSENSTEIN RE; DE ZAVALÍA, NURIA; KELLER SARMIENTO MI; LANZANI, MF; BELFORTE NA
Lugar:
Potrero de los Funes, San Luis
Reunión:
Simposio; XLVII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB), Simposio de Neurociencias; 2011
Institución organizadora:
XLVII Reunión Anual de la Sociedad Argentina de Investigación en Bioquímica y Biología Molecular (SAIB)
Resumen:
Presentación Power Point
Glaucoma
is a leading cause of blindness, due to retinal ganglion cells (RGC) death and
optic nerve damage. Retinal ischemia participates in glaucomatous damage. Recent
evidences indicate that a population of RGC is intrinsically photosensitive
(through the expression of a fotopigment, melanopsin), and transmits light
information to the suprachiasmatic nuclei (SCN), the principal pacemaker for
circadian rhythms. We analyzed: 1) the
effect of ischemic conditioning on retinal damage induced by experimental
glaucoma, and 2) the non-image forming visual system in experimental and
human glaucoma. Weekly
injections of vehicle or chondroitin
sulfate were performed in the rat eye anterior chamber for 10 weeks.
Ischemic conditioning was induced by weekly increasing intraocular pressure to
120 mmHg for 5 min. Brief ischemia pulses reversed the effect of glaucoma on
retinal function and histology. Experimental glaucoma induced alterations in
melanopsin levels, light suppression of nocturnal pineal melatonin, and
light-induced c-Fos expression in the SCN. Glaucomatous animals exhibited an
increase in the diurnal activity, and glaucomatous
patients showed a significant decrease in the sleep quality.
Conclusion: The induction of ischemic tolerance could constitute
a new therapeutic strategy for glaucoma treatment. Glaucoma induced significant
alterations in the non-image forming visual system.