EFFECT OF A MATERNAL DIET ENRICHED IN EXTRA VIRGIN OLIVE OIL ON PROINFLAMMATORY MARKERS AND LIPID PROFILE IN CORD BLOOD FROM GDM PREGNANCIES

GOMEZ RIBOT, DALMIRO; GOMEZ, HEBE LORENA; JAWERBAUM, ALICIA; FAZIO, MARÍA VICTORIA; CAPOBIANCO, EVANGELINA; DÍAZ, ESTEBAN; GRESTA, CARLOS

Buenos Aires (virtual)

Congreso; Reunión de Sociedades de Biocencias; 2021

SAIC

Objectives: Gestational diabetes mellitus (GDM) is a prevalent disease that increases the risk of maternal and fetal complications. Previously, we found that a maternal diet enriched in extra virginolive oil (EVOO) reduced the levels of proinflammatory markers and triglycerides (TG) in maternal blood from GDM pregnancies. Here, we aim to determine whether proinflammatory markers (interleukin 6 (IL-6) and inducible nitric oxide synthase (iNOS)), lipid profile and the lipid chaperone Fatty Acid Binding Protein 4 (FABP4) levels are altered in umbilical cord blood from pregnancies with GDM treated or not with a diet enriched in EVOO.Methods: Fifty healthy (Control) and GDM patients were enrolled (protocol approved by Hospital Pirovano Ethics Committee) and advised to follow the WHO diet for pregnancy. GDM patients wererandomized to receive or not 36 g/day of EVOO from week 24-28 of gestation until delivery. At delivery, cord blood was obtained to evaluate iNOS, IL-6 and FABP4 levels (Western blot), and TG, Total and HDL-Cholesterol (TC, HDL-C; colorimetric assay).Results: Neither IL-6 nor iNOS were altered in the three evaluated groups compared to the controls. TG and HDL-C levels were decreased in umbilical cord blood from the GDM group compared tocontrols (25% and 7% respectively, p