Paternal programming of metabolic alterations in the placenta.

DAIANA FORNES, FLORENCIA HEINECKE, VERÓNICA WHITE, ALICIA JAWERBAUM, EVANGELINA CAPOBIANCO.

Simposio; International Symposium on Reproductive Health 2021; 2021

Paternal exposure to diabetes can lead to the transmission of metabolic disorders in the offspring. Our aim was to evaluate the regulation of lipid metabolism in the placenta of male fetuses (F2) from healthy pregnant rats that were mated with male diabetic rats (F1).Control (C) and type 2 diabetic male rats (D, diabetes obtained by intrauterine programming, glycemia 140-190 mg/dL) were mated with control female rats. On day 21 of gestation, the pregnant and male rats were euthanized. The placentas, the fetuses and fetal and paternal plasma were obtained for further evaluation. In the paternal and fetal plasma of D group, the levels of triglycerides and cholesterol were increased (p