CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Possible involvement of stress hormones and hyperglycaemia in chronic
Autor/es:
MR RUBINSTEIN; G. A. CREMASCHII; L. M. OLIVERI; N. GEREZ; M.R. WALD; A.M. GENARO
Revista:
STRESS
Editorial:
TAYLOR & FRANCIS LTD
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 13 p. 384 - 391
ISSN:
1025-3890
Resumen:
Stress, an important aspect of modern life, has long been associated with an altered homeostatic state. Little is known about
the effect of the life stress on the outcome of diabetes mellitus, especially related to the higher risk of infections. Here, we
evaluate the effects of chronic mild stress (CMS) exposure on the evolution of type I diabetes induced by streptozotocin
administration in BALB/c mice. Exposure of diabetic mice to CMS resulted in a significant reduction of survival and a
sustained increase in blood glucose values. Concerning the immune response, chronic stress had a differential effect in mice
with diabetes with respect to controls, showing a marked decrease in both T- and B-cell proliferation. No correlation was
found between splenic catecholamine or circulating corticosterone levels and the proliferative response. However, a significant
negative correlation was found between glucose levels and concanavalin A- and lipopolysaccharide-stimulated proliferative
responses of Tand B cells. A positive correlation between blood glucose and splenic catecholamine concentrations was found
in diabetic mice but not in controls subjected to CMS. Hence, the present report shows that diabetic mice show a worse
performance in immune function after stress exposure, pointing to the importance of considering life stress as a risk factor for
patients with diabetes