CEFYBO 02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Secretory Leukocyte Proteinase Inhibitor In The Perfusion Solution Helps To Identify Graft Quality In Kidney Transplants
Autor/es:
OSELLA, F.; TONIOLO, F; CASADEI, D.; AMBROSI, N; DIAZ-ALVAREZ, L.; GUERRIERI, D.; CARO, F; CHULUYAN, E.; SÁNCHEZ, F; INCARDONA, C.
Revista:
BIOMARKERS IN MEDICINE
Editorial:
FUTURE MEDICINE LTD
Referencias:
Lugar: Londres; Año: 2019
ISSN:
1752-0363
Resumen:
Background: It is important to find biomarkers that identify the graft quality in kidney transplantation. Results/Methodology: The level of secretory leukocyte proteinase inhibitor (SLPI) in the cold preservation solution was used as a marker to predict early kidney graft function after transplantation. Before transplantation, kidneys were washed and SLPI was measured in the discarded solution. A retrospective analysis showed that patients with delay graft function (DGF) or rejection episodes post-transplant had higher SLPI concentrations than did patients without DGF or rejections. Furthermore, SLPI could discriminate between patients with better or worse eGFR among low-risk patients (KDPI
