Prostate Cancer, High Cortisol Levels and Complex Hormonal Interaction.

GROSMAN H; REPETTO EM; MAZZA O; GROSMAN H; REPETTO EM; MAZZA O; GONZALEZ D; MESCH V; BERG G; GONZALEZ D; MESCH V; BERG G; FABRE B; FERNÁNDEZ MACHULSKY N; LOPEZ MA; FABRE B; FERNÁNDEZ MACHULSKY N; LOPEZ MA

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION

ASIAN PACIFIC ORGANIZATION CANCER PREVENTION

Año: 2016 vol. 17 p. 3167 - 3171

1513-7368

Prostate cancer (PCa) is one of the most common diseases in men. It is important to assess prognostic factors and whether high cortisol levels and complex hormonal interactions could be responsible for PCa development. We evaluated the relationship between cortisol, leptin and estrogens in 141 men, 71 with PCa and the remaining 70 constituting a low risk group (LRG). They were recruited for this study from a total of 2906 middleaged men (ages 4570 years) who completed an evaluation for prostatic diseases at the Urology Division, Hospital de Clinicas "Jose de San Martin", University of Buenos Aires, in May 2009. In this cross sectional study, cortisol, PSA, totaltestosterone, freetestosterone, bioavailable testosterone, LH and estradiol were measured in serum. We observed increased cortisol levels in PCa patients as compared to LRG cases (p0.004,). Leptin and estradiol levels were also higher in PCa patients (p0.048; p