The effects of maternal dietary treatments with natural PPAR ligands on lipid metabolism in fetuses from control and diabetic rats.

CAPOBIANCO EVANGELINA; MARTÍNEZ NORA; HIGA ROMINA; WHITE VERÓNICA; JAWERBAUM ALICIA

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

CHURCHIL LIVINGSTONE

Lugar: Edimburgo; Año: 2008 vol. 79 p. 191 - 199

0952-3278

Maternal diabetes impairs fetal development and growth. We studied the effects of maternal diets enriched inunsaturated fatty acids capable of activating peroxisome proliferator-activated receptors (PPARs) on the concentrations of 15deoxyD12,14PGJ2 (15dPGJ2), lipid mass, an the de novo lipid synthesis in13.5-day fetuses from control and diabetic rats. Diabetes was induced by neonatal streptozotocina administration (90mg/kg). Rats were treated with a standard diet supplemented or not with 6% olive oil or 6% safflower oil from days 0.5 to 13.5 of gestation. Fetuses from diabetic rats fed with the standard diet showed reduced15dPGJ2 concentrations, whereas maternal treatments with olive and safflower oils increased15dPGJ2 concentrations. Fetuses from diabetic rats showed increased concentrations of phospholipids and increased synthesis of triglycerides, phospholipids, cholesterol and free fatty acids. Diabetic rat treatments with olive and safflower oils reduced phospholipids, cholesterol, and free fatty acid concentrations and the de novo lipid synthesis in the fetuses. These effects were different from those observed in fetuses from control rats, and seem not to involve PPARã activation. In conclusion, olive oil-and safflower oil-supplemented diets provide beneficial effects in maternal diabetes, as they prevent fetal impairments in 15dPGJ2 concentrations, lipids synthesis and lipid accumulation.