CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Induction of ischemic tolerance as a promising treatment against diabetic retinopathy.
Autor/es:
ROSENSTEIN RE; FERNADEZ DC
Revista:
NEURAL REGENERATION RESEARCH
Editorial:
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
Referencias:
Lugar: Mumbai ; Año: 2014 vol. 9 p. 1581 - 1584
ISSN:
1673-5374
Resumen:
Neural Regen Res. 2014 Sep 1;9(17):1581-4. doi: 10.4103/1673-5374.141782. Induction of ischemic tolerance as a promising treatment against diabetic retinopathy. Rosenstein RE1, Fernandez DC2. Author information Abstract Diabetic retinopathy is a leading cause of acquired blindness, and it is the most common ischemic disorder of the retina. Available treatments are not very effective. Efforts to inhibit diabetic retinopathy have focused either on highly specific therapeutic approaches for pharmacologic targets or using genetic approaches to change expression of certain enzymes. However, it might be wise to choose innovative treatment modalities that act by multiple potential mechanisms. The resistance to ischemic injury, or ischemic tolerance, can be transiently induced by prior exposure to a non-injurious preconditioning stimulus. A complete functional and histologic protection against retinal ischemic damage can be achieved by previous preconditioning with non-damaging ischemia. In this review, we will discuss evidence that supports that ischemic conditioning could help avert the dreaded consequences that results from retinal diabetic damage.