Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma.

LANZANI, MF; DE ZAVALÍA NURIA; FONTANA HÉCTOR; SARMIENTO MI; GOLOMBEK D; ROSENSTEIN R.E.

CHRONOBIOLOGY INTERNATIONAL

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2012 vol. 29 p. 911 - 919

0742-0528

Chronobiol Int. 2012 Aug;29(7):911-9. doi: 10.3109/07420528.2012.691146. Alterations of locomotor activity rhythm and sleep parameters in patients with advanced glaucoma. Lanzani MF, de Zavalía N, Fontana H, Sarmiento MI, Golombek D, Rosenstein RE. Source Laboratory of Retinal Neurochemistry and Experimental Ophthalmology, Department of Human Biochemistry, School of Medicine, University of Buenos Aires/CEFyBO, CONICET, Buenos Aires, Argentina. Abstract The aim of this study was to evaluate the effect of advanced glaucoma on locomotor activity rhythms and related sleep parameters. Nine normal subjects and nine age-matched patients with bilateral advanced primary open-angle glaucoma, >10 yrs since diagnosis, were included in this observational, prospective, case-control study. Patients were required to record the timing and duration of their sleep and daily activities, and wore an actigraph on the wrist of the nondominant arm for 20 d. Activity rhythm period, MESOR (24-h time-series mean), amplitude (one-half peak-to-trough variation), and acrophase (peak time), plus long sleep episodes during the wake state, sleep duration, efficiency, and latency, as well as mean activity score, wake minutes, and mean wake episodes during the sleep interval were assessed in controls and glaucomatous patients. Glaucomatous patients exhibited significant decrease in nighttime sleep efficiency, and significant increase in the mean activity score, wake minutes, and mean wake episode during the night. These results suggest that alterations of circadian physiology could be a risk to the quality of life of patients with glaucoma.