CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
The Role of Toll-like Receptors in the ImmuneAdrenal Crosstalk
Autor/es:
S.R. BORNSTEIN; C.G. ZIEGLER; A.W. KRUG; W. KANCZKOWSKI; V. BESUHLI DE RETTORI; S.M. MCCANN; M. WIRTH; K. ZACHAROWSKI
Revista:
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES.
Referencias:
Año: 2006 vol. 1088 p. 307 - 318
ISSN:
0077-8923
Resumen:
Sepsis and septic shock remain major health concernsworldwide,
and rapid activation of adrenal steroid release is a key event in the
organisms first line of defense during this form of severe illness. Tolllike
receptors (TLRs) are critical in the early immune response upon
bacterial infection, and recent data from our lab demonstrate a novel
link between the innate immune system and the adrenal stress response
mediated by TLRs. Glucocorticoids and TLRs regulate each other in
a bidirectional way. Bacterial toxins acting through TLRs directly activate
adrenocortical steroid release. TLR-2 and TLR-4 are expressed in
human and mice adrenals and TLR-2 deficiency is associated with an impaired
glucocorticoid response. Furthermore, TLR-2 deficiency in mice
is associated with marked cellular alterations in adrenocortical tissue.
TLR-2-deficient mice have an impaired adrenal corticosterone release
following inflammatory stress induced by bacterial cell wall compounds.
This defect appears to be associated with a decrease in systemic and intraadrenal
cytokine expression. In conclusion, TLRs play a crucial role
in theimmuneadrenal crosstalk. This close functional relationship needs
to be considered in the treatment of inflammatory diseases requiring an
intact adrenal stress response.