CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
artículos
Título:
Animal Models in Diabetes and Pregnancy
Autor/es:
JAWERBAUM ALICIA; WHITE VERÓNICA
Revista:
ENDOCRINE REVIEWS.
Editorial:
ENDOCRINE SOC
Referencias:
Año: 2010 p. 680 - 701
ISSN:
0163-769X
Resumen:
The worldwide increase in the incidence of diabetes, the increase in type 2 diabetes in women at reproductive
ages, and the cross-generation of the intrauterine programming of type 2 diabetes are the bases for the growing
interest in the use of experimental diabetic models in order to gain insight into the mechanisms of induction
of developmental alterations in maternal diabetes.
In this scenario, experimental models that present the most common features of diabetes in pregnancy are
highly required. Several important aspects of human diabetic pregnancies such as the increased rates of spontaneous abortions, malformations, fetoplacental impairments, and offspring diseases in later life can be approached by using the appropriate animal models. The purpose of this review is to give a practical and critical
guide into the most frequently used experimental models in diabetes and pregnancy, discuss their advantages
and limitations, and describe the aspects of diabetes and pregnancy for which these models are thought to be
adequate. This review provides a comprehensive view and an extensive analysis of the different models and
phenotypes addressed in diabetic animals throughout pregnancy. The review includes an analysis of the surgical,
chemical-induced, and genetic experimental models of diabetes and an evaluation of their use to analyze early
pregnancy defects, induction of congenital malformations, placental and fetal alterations, and the intrauterine
programming of metabolic diseases in the offsprings later life. (Endocrine Reviews 31: 680 701, 2010)