INGEBI   02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Strength of the efferent olivocochlear system modifies the normal activity of a central auditory nuclei
Autor/es:
DI GUILMI, MARIANO NICOLÁS; GÓMEZ-CASATI, MARÍA EUGENIA; BOERO, LUIS EZEQUIEL; ELGOYHEN, ANA BELÉN
Lugar:
Mar del Plata
Reunión:
Congreso; XXX Reunión Anual de la Sociedad Argentina de Neurociencias. Mar del Plata, Argentina. 2015.; 2015
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
The auditory system in several mammals is immature atbirth but precisely organized in adults. Spontaneous activityof inner hair cells before the onset of hearing may come intoplay to guide this process. The rate of this spontaneousactivity is under the control of an olivocochlear efferentpathway(MOC) that descends from the brain.Along the auditory pathway neurons are tonotopicallyorganized, with cells that are grouped according to theirfrequency selectivity. Particularly, in the medial nucleus ofthe trapezoid body (MNTB) neurons are spatiallyorganized along a medio-lateral axis with the most mediallylocated cells responding best to high frequency sounds andlateral cells to low frequency. In this work we studied theMNTB tonotopy in the KI mouse, an animalmodel with enhanced efferent functionality