INGEBI   02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Selective Attention to Visual Stimuli in α9-Nicotinic Acetylcholine Receptor Knock-out Mice
Autor/es:
TERREROS G; JORRAT P; ELGOYHEN AB; DELANO P
Reunión:
Congreso; 37th Midwinter Meeting, Association for Research in Otolaryngology; 2015
Resumen:
The auditory efferent system is a unique neural network originated in the auditory cortex that projects to the medial geniculate body, inferior colliculus, cochlear nucleus and superior olivary complex, reaching the cochlea through the olivocochlear fibers (FIG. 1). The medial olivocochlear (MOC) bundle comprises a group of efferent myelinated fibers that mainly project from ventral brainstem to the contralateral cochlea. MOC neurons make synaptic contacts with outer hair cells (OHC), releasing acetylcholine that opens 9/10 nicotinic receptors located in the basolateral membrane of OHCs. One of the possible roles of the efferent system is to filter irrelevant auditory signals during selective attention to visual stimuli (Delano et al., 2007). Here, we used a visual discrimination task with and without auditory distractors to find behavioral differences in the 9-nicotinic acetylcholine receptor knock-out (KO) and wild type (WT) mice