INGEBI   02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Synthesis of heterocyclic amines and alcohols
Autor/es:
PAOLA BIANCHI; ROMINA FERNANDEZ VARELA; DARIO BIANCHI; ADOLFO IRIBARREN; LEWKOWICZ, ELIZABETH
Lugar:
Viena
Reunión:
Simposio; Simposio Internacional de Biocatalisis y Biotransformaciones (BIOTRANS 2015; 2015
Resumen:
CALB-catalysed biotransformations presented give a simple, versatile and highly regioselective access to a set of potential fludarabine prodrugs. Derivatives bearing different acylation degree as well as regioisomers can be prepared by this methodology. In deacylation reactions, the regioselectivity of the lipase can be modified by choice of the reaction medium. On the whole, this strategy based on the same lipase catalysing deacylation and acylation reactions improves conventional synthesis of nucleoside prodrugs, since it avoids protective steps and involves simple reagents.