INGEBI 02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
artículos
Título:
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity.
Autor/es:
ZINGALES B; MILES MA; MORAES C; LUQUETTI AO,; FELIPE GUHL; ALEJANDRO G. SCHIJMAN,; RIBEIRO I,
Revista:
MEMóRIAS DO INSTITUTO OSWALDO CRUZ.
Editorial:
FUNDACO OSWALDO CRUZ
Referencias:
Lugar: Rio de Janeiro; Año: 2014 vol. 109 p. 828 - 833
ISSN:
0074-0276
Resumen:
This opinion piece presents an approach to standardisation of an
important aspect of Chagas disease drug discovery and development:
selecting Trypanosoma cruzi strains for in vitro screening. We discuss
the rationale for strain selection representing T. cruzi diversity and
provide recommendations on the preferred parasite stage for drug
discovery, T. cruzi discrete typing units to include in the panel of
strains and the number of strains/clones for primary screens and lead
compounds. We also consider experimental approaches for in vitro drug
assays. The Figure illustrates the current Chagas disease drug-discovery
and development landscape.
