INGEBI 02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
artículos
Título:
Expanding the toolbox for enantioselective sulfide oxidations: Streptomyces strains as biocatalysts
Autor/es:
MARÍA LAURA MASCOTTI; MARTÍN PALAZZOLO; ELIZABETH LEWKOWICZ; MARCELA KURINA
Revista:
Biocatalyst and Agricultural Biotechnology
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2013 vol. 2 p. 399 - 402
ISSN:
1878-8181
Resumen:
Sulfide oxidase activity ofStreptomycesgenus is reported here for thefirst time. Three Streptomyces strains were selected as new tools to access to enantioenrichedR- andS-dialkyl sulfoxides. The bacterial screening was carried out using cyclohexyl methyl sulfide as model substrate. Both sulfoxide antipodes were obtained in a one-pot, time-dependent biotransformation employingStreptomyces phaeochromogenes NCIMB 11741 as biocatalyst.Streptomyces flavogriseusATCC 33331produced mainly the S-enantiomer, while Streptomyces hiroshimensisATCC 27429 yielded enantiopureR-cyclohexyl methyl sulfoxide.
