INGEBI   02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
artículos
Título:
Phenotypic Characteristics of Hyperacusis in Tinnitus
Autor/es:
SCHECKLMANN M; LANDGRAEBE M; LANGGUTH B; TINNITUS RESEARCH INITIATIVE DATABASE GROUP: VIELSMEIER V, KLEINJUNG T, LEHNER A, KREUZER P, POEPPL TB, FIGUEIREDO R, AZEVEDO A, BINETTI A, ELGOYHEN AB, RATES M, COELHO C, VANNESTE S, DE RIDDER D, VAN DE HEYNING P, ZEMAN F, KOLLER M
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2014 vol. 9 p. 86944 - 86944
ISSN:
1932-6203
Resumen:
Background: Many people with tinnitus also suffer from hyperacusis. Both clinical and basic scientific data indicate an overlap in pathophysiologic mechanisms. In order to further elucidate the interplay between tinnitus and hyperacusis we compared clinical and demographic characteristics of tinnitus patients with and without hyperacusis by analyzing a large sample from an international tinnitus patient database. Materials: The default dataset import [November 1 st , 2012] from the Tinnitus Research Initiative [TRI] Database was used for analyses. Hyperacusis was defined by the question ??Do sounds cause you pain or physical discomfort??? of the Tinnitus Sample Case History Questionnaire. Patients who answered this question with ??yes?? were contrasted with ??no??-responders with respect to 41 variables.Results: 935 [55%] out of 1713 patients were characterized as hyperacusis patients. Hyperacusis in tinnitus was associated with younger age, higher tinnitus-related, mental and general distress; and higher rates of pain disorders and vertigo. In relation to objective audiological assessment patients with hyperacusis rated their subjective hearing function worse than those  without  hyperacusis.  Similarly  the  tinnitus  pitch  was  rated  higher  by  hyperacusis  patients  in  relation  to  the audiometrically determined tinnitus pitch. Among patients with tinnitus and hyperacusis the tinnitus was more frequently modulated  by  external  noise  and  somatic  maneuvers,  i.e.,  exposure  to  environmental  sounds  and  head  and  neck movements change the tinnitus percept.Conclusions: Our findings suggest that the comorbidity of hyperacusis is a useful criterion for defining a sub-type of tinnitus which is characterized by greater need of treatment. The higher sensitivity to auditory, somatosensory and vestibular input confirms the notion of an overactivation of an unspecific hypervigilance network in tinnitus patients with hyperacusis.