INGEBI 02650
INSTITUTO DE INVESTIGACIONES EN INGENIERIA GENETICA Y BIOLOGIA MOLECULAR "DR. HECTOR N TORRES"
Unidad Ejecutora - UE
artículos
Título:
Organocatalytic synthesis of novel purine and pyrimidine acyclic nucleosides
Autor/es:
M. PALAZZOLO; M. PÉREZ-SÁNCHEZ; A IRIBARREN; E LEWKOWICZ; P. DOMÍNGUEZ DE MARÍA
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 53 p. 6797 - 6800
ISSN:
0040-4039
Resumen:
Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up procedures. Nucleobases containing aldehydes are catalytically ligated (CC bond formation) to acetone or to phosphonate-containing ketones by means of pyrrolidine or silica-immobilized piperazine as amine-based organocatalysts.
