IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Chlorpyrifos promotes the migration of breast cancer cells activating c-Src, AKT, GSK-3β and P38 pathways.
Autor/es:
MARIANELA LASAGNA; MARIANA MARDIROSIAN; MARIEL NUÑEZ; CLARA VENTURA ; NOELIA MIRET; CLAUDIA COCCA; SOLEDAD HIELPOS; ANDREA RANDI
Lugar:
Modalidad Virtual
Reunión:
Otro; Reunión Anual de Sociedades de Biociencias - SAIC- SAI - SAFIS; 2020
Institución organizadora:
SAIC
Resumen:
Chlorpyrifos (CPF) is a pesticide whose effects do not have consensus concerning breast cancer risk. Our aim was to analyze whether CPF promotes migration and the pathways involved in MCF-7 and MDA-MB-231 cell lines. Migration was evaluated by 2D (wound healing and Boyden Chamber assays) and 3D assays (multicellular spheroids). The role of c-Src, AKT, P38 and GSK3-β were studied by Western Blot. In MCF-7 cells, 0.05 µM CPF induced the migration after 48 h (p
