IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
CARDIOTOXIC EFFECTS OF THE ANTINEOPLASIC DOXORUBICIN IN A MODEL OF METABOLIC SYNDROME: OXIDATIVE STRESS AND TRANSPORTERS EXPRESSION IN THE LEFT VENTRICLE
Autor/es:
OGONOWSKI N; ROSÓN, MARÍA INÉS; CELUCH SM; RUKAVINA MIKUSIC, NATALIA LUCÍA; CHOI MR; KOUYOUMDZIAN NM; FELLET A; AM BALASZCZUK; OGONOWSKI N; ROSÓN, MARÍA INÉS; CELUCH SM; RUKAVINA MIKUSIC, NATALIA LUCÍA; CHOI MR; KOUYOUMDZIAN NM; FELLET A; AM BALASZCZUK
Reunión:
Congreso; LXIII Reunión Anual de la Sociedad Argentina de Investigación Clínica (SAIC); 2018
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC)
Resumen:
Doxorubicin (DOX) clinical use as chemotherapeutic agent is limited due to the development of cardiomyopathies and heart failure.In the present study we aimed to examine whether Metabolic Syndrome-like conditions in rats, generated by administration of 10% fructose in the drinking water, modify the adverse effects induced by a single dose of DOX and whether the treatment modifies the expression of P-glycoprotein (P-gp) and organic cation/carnitine transporter OCT-N2 in the heart.Male Sprague-Dawley rats receiving either tap water (C, control) or water with 10% fructose (F) during 8 weeks were treated with DOX (6 mg/kg, ip, md) or vehicle (V) (n=4/group). Three days after injection, echocardiographic monitoring was performed and then rats were sacrificed. Left ventricles were excised to measure oxidative stress markers and protein expression of P-gp and OCTN1/2/3 by western blot.F increased TBARS tissue levels and decreased the activity of the antioxidant enzyme SOD (p