IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Growth hormone administration patterns have different molecular effects in female mice breast tissue
Autor/es:
NADIA SOFÍA CICCONI; JOHANNA GABRIELA MIQUET; MARÍA EUGENIA DÍAZ; LORENA GONZALEZ; MARIANA ANDREA BOJORGE; ANA ISABEL SOTELO
Lugar:
Mar del Plata
Reunión:
Congreso; LXIII REUNION ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION CLINICA (SAIC); 2018
Resumen:
Recombinant growth hormone (GH) is used for the treatment of different pathologies, including pediatric and adult GH deficiency, chronic renal insufficiency, Turner syndrome and cachexia secondary to AIDS. The main disadvantages of GH administration are the short half-life of the hormone, its renal toxicity and the necessity of multiple injections which turns the treatment stressing and uncomfortable for patients; thus, GH is a good candidate for depot formulations producing continuous release of the hormone. However, the effects of different GH-administration modes over cell proliferation and tumorigenesis are not known.High GH levels have been associated with the development of tumors, including breast cancer, in humans and different mice models. Therefore, the aim of the present work is to study the differential effects of GH administration patterns, intermittent and continuous, on the expression of receptors involved in mammary tissue growth and development, and the engagement of signaling pathways involved in cell proliferation and survival.