IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Effect of the quercetin on the calcium transport through biological membranes.
Autor/es:
VIGIL, M; MANGIALAVORI, I.; FERREIRA-GOMES, M; ONTIVEROS, M.; MARDER, MARIEL; ROSSI, RC ; RINALDI, D.; ESPELT, M; ROSSI, J P
Lugar:
Ciudad Autónoma de Buenos Aires
Reunión:
Simposio; Simposio Fronteras en Biociencia 3, Jornada de Jóvenes científicos; 2018
Resumen:
Recently, there has been increasing interest in the research on flavonoids from plant sources because of their beneficial properties for health [1]. Several studies have attributed them anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme functions. Flavonoids exert their effect in different ways, in particular, there are flavonoids related with changes of intracellular calcium concentration suggesting that they could affect the calcium transport, including the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase and the plasma membrane Ca2+-ATPase (PMCA) [2-8]. However, the molecular mechanisms underlying this effect are not yet clear. This work seeks to investigate the effect of a flavonoid -quercetin- on PMCA4, a calmodulin regulated P-type ATPase responsible for the preservation of low intracellular Ca2+ concentration in all the eukaryotic cell