PESTICIDES IN THE SIGHT: ACTION OF HEXACHLOROBENZENE AND CHLORPYRIFOS IN TUMOR ANGIOGENESIS IN BREAST CANCER MODELS

PONTILLO CA ; CHIAPPINI F; KLEIMAN DE PISAREV DL; ZÁRATE LV ; MIRET NV ; ÁLVAREZ L ; RANDI AS; ESPAÑOL A; COCCA C ; SALES ME

Buenos Aires

Congreso; Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Investigación Clínica

Hexachlorobenzene (HCB) is an organochlorine compound found in maternal milk and in lipid foods. Chlorpyrifos (CPF) is an organophosphate pesticide used for pest control in agriculture. Breast cancer is by far the most frequently diagnosed cancer in women. HCB and CPF act as endocrine disruptors stimulating cell proliferation in different breast cancer models. Vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) promote tumor proliferation and angiogenesis. Nitric oxide (NO) and abnormal expression of nitric oxide synthases (NOS1, NOS2, NOS3) are implicated in cancer biology and tumor progression. We examined the action of HCB and CPF on angiogenesis in mammary carcinogenesis in vivo and in vitro. In a xenograft model with MCF-7(+ERα), HCB (3 mg/kg bw) and CPF (0.1 mg/kg bw) stimulated angiogenic switch (number of vessels/mm2) (HCB p