N-butyl-1,2,3-oxathiazolidine-4-one-2,2-dioxide, a new anticonvulsant compound with antioxidant properties.

PASTORE, VALENTINA; WASOWSKI, CRISTINA; MARDER, MARIEL

Huerta Grande, Cordoba

Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2012

Sociedad Argentina de Investigación en Neurociencias

Epilepsy is recognized as one of the most common and serious neurological disorder affecting 1-2% of the world?s population. Among various factors supposed to play role in epilepsy, oxidative stress and reactive species (ROS) in seizure disorders have recently emerged. The most important effect of free radicals is lipid peroxidation (LP), which causes disruption of cell membrane thereby leading to their destruction. An increased of free radicals also decreased glutathione (GSH) concentration in the epileptic focus. We have synthesized a bioisoster of trimethadione (a classical anticonvulsant), N-butyl-1,2,3-oxathiazolidine-4-one-2,2-dioxide, which showed anticonvulsant properties in MES and PTZ test. This new anticonvulsant with ED50 of 18 mg/kg (scPTZ), has been tested for its antioxidant properties. N-butyl-1,2,3-oxathiazolidine-4-one-2,2-dioxide administrated before PTZ treatment countered the effects of PTZ and protected brain from oxidative stress by decreasing the LP and restoring the GSH content.