IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Altered male hypothalamic- pituitary- testicular axis as a consequence of prenatal stress exposure
Autor/es:
PALLARÉS M.E.; GONZÁLEZ- CALVAR S.I; BOURGUIGNON N.S; ADROVER E.; KATUNAR M.R.; BAIER C.J; LUX-LANTOS V.; CALANDRA R.S.; ANTONELLI M.C.
Lugar:
Atenas
Reunión:
Congreso; 23rd Bienal Meeting of ISN- ESN.; 2011
Institución organizadora:
ISN- ESN
Resumen:
Adolescence is a phase of life when the brain awakens to pleasure and risk. In addition, it is a pivotal time on the etiology of a range of psychopathologies including schizophrenia, substance of abuse disorders and depression. During this time of life, gonadal hormones exert its effects on peripheral tissues inducing the appearance of secondary sex characteristics. Furthermore they also act centrally to influence both the remodeling of the adolescent brain and behavioral maturation. During the last years, our laboratory has been studying the effects of prenatal stress (PS) on dopaminergic (DA) metabolism development and found that PS exerted impairments in DA limbic brain areas which malfunction are involved on the psychopathologies recently mentioned. We noticed that those impairments appears after puberty. Since gonadal hormones can influence DA system development by inducing plastic changes in the brain, and since gestational stress was also reported to induce long term effects on the progeny hormonal serum levels, a disbalanced hormone milieu (as a consequence of the prenatal stress insult) might be responsible for the DA metabolism alterations observed in our previous studies. Based upon these observations, the aim of the present study was to further evaluate severa aspects of the hypothalamic‐ pituitary‐testicular (HPT) axis status of males rats exposed to prenatal stress by immobilization of the pregnant dam.