Transferrin effects on Subventricular zone-derived cells in Vitro

SILVESTROFF L; FRANCO P; PASQUINI, J.

Río de Janeiro

Encuentro; 1st Meeting of the Institute of Glia: A South American Alliance (iGlia); 2011

iGlia

Neural Stem Cells and Neural Progenitor Cells (NSC/NPC) are multipotent and capable of giving rise to neurons, astrocytes and oligodendrocytes in the Central Nervous System (CNS) in rodents and in humans, both during development and adulthood. The Subventricular zone (SVZ) is known to be the largest niche within the SNC to harbour NSC/NPC in vivo. We decided to culture SVZ tissue fragments belonging to newborn rats under the form of neurospheres to evaluate Tf effects on cell proliferation. The results of this study indicate Tf in vitro is able to increase cell proliferation. Furthermore, they suggest glial restricted progenitors and oligodendrocyte progenitor cells are responsible for the increase in SVZ-derived culture proliferation.