IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Protein auto association, concentration, and temperature: Insulin as an example.
Autor/es:
PAVÁN, CARLOS; ANNIBALI, NESTOR; CURTO L.M.; BALLATORE, M; CARLUCCI, A; GOMEZ, MARTÍN; DELFINO J.M.
Reunión:
Congreso; XLVIII Reunión Anual de la Sociedad Argentina de Biofísica; 2021
Institución organizadora:
Sociedad Argentina de Biofísica
Resumen:
Insulin is one of the most medically relevant biomolecules and, at least in part, its fame is due to its close link with diabetes, a major public health problem worldwide. Like most recombinant proteins that are used as biotherapeutics, conformational changes suffered by insulin might lead to reduced clinical efficacy and, ultimately, to immunological reactions that preclude its use. Despite its low molecular weight (
