Advances in Lipid research

NORMA STERIN-SPEZIALE; FRANCISCO LEOCATA-NIETO; LUCILA G PESCIO; NICOLÁS O FAVALE

Sphingolipid metabolism as regulator of cell behavior

Research Singpost

Año: 2007;

influence of sphingolipid metabolism in determining cellular fate. In non-stimulated proliferating MDCK cells, sphingolipid de novo synthesis is mainly branched to a production of sphingomyelin and ceramide, with a minor production of sphingosylphosphocholine, ceramide-1-phosphate and sphingosine-1-phosphate. Experiments with 32P as a radioactive precursor showed that sphingosine-1-phosphate is mainly produced by a de novo-independent pathway. Enzymatic inhibitions of the de novo pathway and ceramide32P as a radioactive precursor showed that sphingosine-1-phosphate is mainly produced by a de novo-independent pathway. Enzymatic inhibitions of the de novo pathway and ceramide