Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 and angiopoietin-like protein 4 are associated with the increase of lipoprotein lipase activity in epicardial adipose tissue from diabetic patients.

SCHREIER L; BALDI J; RUBIO M; BARCHUK M; CEVEY A,; GOREN N; BERG G; BARCHUK M; CEVEY A,; GOREN N; BERG G; LÓPEZ G; FERNANDEZ TOMÉ MDC; MIKSZTOWICZ V; LÓPEZ G; FERNANDEZ TOMÉ MDC; MIKSZTOWICZ V; SCHREIER L; BALDI J; RUBIO M

ATHEROSCLEROSIS

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2019 vol. 288 p. 51 - 59

0021-9150

Epicardial adipose tissue (EAT) is a visceral AT, surrounding myocardium and coronary arteries. Its volume is higher in Type 2 diabetic (DM2) patients, associated with cardiovascular disease risk. Lipoprotein lipase (LPL) hydrolyses triglycerides (TG) from circulating lipoproteins, supplying fatty acids to AT, contributing to its expansion. We aimed to evaluate LPL expression and activity in EAT from DM2 and no DM2 patients, and its regulators ANGPTL4, GPIHBP1 and PPARγ levels, together with VLDLR expression and EAT LPL association with VLDL characteristics. METHODS: We studied patients undergoing coronary by-pass graft (CABG) divided into CABG-DM2 (n = 21) and CABG-noDM2 (n = 29), and patients without CABG (No CABG, n = 30). During surgery, EAT and subcutaneous AT (SAT) were obtained, in which LPL activity, gene and protein expression, its regulators and VLDLR protein levels were determined. Isolated circulating VLDLs were characterized. RESULTS:EAT LPL activity was higher in CABG-DM2 compared to CABG-noDM2 and No CABG (p=0.002 and p