IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity
Autor/es:
PÉREZ MARÍA JULIA; GHANEM CAROLINA INÉS; MOTTINO ALDO D; MANAUTOUD JOSÉ E.
Revista:
PHARMACOLOGICAL RESEARCH
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 1009 p. 119 - 131
ISSN:
1043-6618
Resumen:
Acetaminophen (APAP) is a well-known analgesic and antipyretic drug. It is considered to be safe whenadministered within its therapeutic range, but in cases of acute intoxication, hepatotoxicity can occur.APAP overdose is the leading cause of acute liver failure in the northern hemisphere. Historically, studieson APAP toxicity have been focused on liver, with alterations in brain function attributed to secondaryeffects of acute liver failure. However, in the last decade the pharmacological mechanism of APAP as acannabinoid system modulator has been documented and some articles have reported ?in situ? toxicityby APAP in brain tissue at high doses. Paradoxically, low doses of APAP have been reported to producethe opposite, neuroprotective effects. In this paper we present a comprehensive, up-to-date overview ofhepatic toxicity as well as a thorough review of both toxic and beneficial effects of APAP in brain.
