IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Liberation of ATP secondary to hemolysis is not mutually exclusive of regulated export
Autor/es:
KIRBY BS, SCHWARZBAUM PJ, LAZAROWSKI ER, DINENNO FA, &MCMAHON TJ
Revista:
BLOOD, THE JOURNAL OF THE AMERICAN SOCIETY OF HEMATOLOGY - ONLINE
Editorial:
AMERICAN SOCIETY OF HEMATOLOGY
Referencias:
Año: 2015 vol. 125 p. 1844 - 1845
ISSN:
1528-0020
Resumen:
In their recent report published in Blood,Sikora and colleaguescorrelate cell-free hemoglobin (Hb) and extracellular adenosine triphosphate(ATPec), and conclude that cell rupture from hypotonicshock accounts for ATPec increases in isolated red blood cell (RBC)suspensions. Although this conclusion may apply to the authors?experimental conditions (.25% reduction in tonicity with RBCsfrom hemochromatosis patients, stored 0-14 days), it cannot be generalizedto studies inwhich (patho)physiologically relevant conditions(eg, hypoxia, acidosis, adrenergic stimulation, mechanical stress)were used to promote ATP release from RBCs freshly isolated fromnormal humans independently of hemolysis.
