IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Is DRM lipid composition relevant in cell-extracellular matrix adhesion structures?
Autor/es:
MARÍA GABRIELA MÁRQUEZ; NORMA BEATRIZ STERIN-SPEZIALE
Revista:
Cell adhesion and Migration
Editorial:
Karger
Referencias:
Año: 2008 vol. 2 p. 180 - 188
Resumen:
Focal adhesions mediate cell-extracellular matrix adhesion.
They are inserted in detergent-resistant membrane microdomains
enriched in phosphatidylinositol-4,5-bisphosphate. In spite of
the relevance that membrane lipids appear to have on cell adhesion
structures, to our knowledge, there are no previous reports
on the membrane lipid composition where focal adhesions are
located in vivo or on how changes in local membrane composition
contribute to focal adhesion maintenance. This may be due to the
fact that the explosion of information in the fields of genomics and
proteomics has not been matched by a corresponding advancement
of knowledge in the field of lipids. The physiological importance of
lipids is illustrated by the numerous diseases to which lipid abnormalities
contribute. To gain insight into the role of membrane
lipid composition in the preservation of epithelial cell adhesion
to the substratum, how specific changes in the membrane lipid
composition in vivo affect the maintenance of focal adhesions in
renal papillae collecting duct cells has been previously studied. It
is currently considered that phosphatidylinositol-4,5-bisphosphate
plays a crucial role in the maintenance of assembled focal adhesion.
However, such pool of polyphosphoinositides has to be part of a
domain of a specific lipid composition to serve as a membrane lipid
stabilizing the focal adhesion plaque