IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Increased hypothalamic angiotensin-(1-7) levels in rats with aortic coarctation-induced hypertension
Autor/es:
GIRONACCI MM, BROSNIHAN KB, FERRARIO CM, GORZALCZANY S, LOPEZ VERRILLI MA, PASCUAL M, TAIRA C, PEÑA C
Revista:
PEPTIDES
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 28 p. 1580 - 1585
ISSN:
0196-9781
Resumen:
Since angiotensin (Ang) (1–7) injected into the brain blocked Ang II pressor actions in rats made hypertensive by aortic coarctation (CH), we examined systemic and tissue angiotensin peptide levels, specifically concentrating on the hypothalamic Ang-(1–7) levels. Plasma, heart and kidney isolated from CH rats showed increased levels of Ang I, Ang II and Ang-(1–7) compared with the normotensive group, with Ang II being the predominant peptide in heart and kidney. In the hypothalamus, equimolar amounts of Ang II and Ang-(1–7) were found in the sham group, whereas only Ang-(1–7) levels increased in CH rats. We conclude that aortic coarctation activates systemic and tissue renin–angiotensin system. The increased central levels of Ang-(1–7) in the CH rats suggest a potential mitigating role of this peptide in central control of the hypertensive process.