IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
In vivo and in vitro effects of chromium VI on anterior pituitary hormone release and viability
Autor/es:
AF QUINTEROS; AH B POLIANDRI; LI MACHIAVELLI; JP CABILLA; BH DUVILANSKI
Revista:
TOXICOLOGY AND APPLIED PHARMACOLOGY
Editorial:
Elsevier
Referencias:
Año: 2007 vol. 218 p. 79 - 87
ISSN:
0041-008X
Resumen:
Hexavalent chromium (Cr VI) is a highly toxic metal and an environmental pollutant. Different studies indicate that Cr VI exposure adverselyaffects reproductive functions. This metal has been shown to affect several tissues and organs but Cr VI effects on pituitary gland have not beenreported. Anterior pituitary hormones are central for the body homeostasis and have a fundamental role in reproductive physiology. The aim of thisstudy was to evaluate the effect of Cr VI at the pituitary level both in vivo and in vitro. We showed that Cr VI accumulates in the pituitary andhypothalamus, and decreases serum prolactin levels in vivo but observed no effects on LH levels. In anterior pituitary cells in culture, the effect ofCr VI on hormone secretion followed the same differential pattern. Besides, lactotrophs were more sensitive to the toxicity of the metal. As a resultof oxidative stress generation, Cr VI induced apoptosis evidenced by nuclear fragmentation and caspase 3 activation. Our results indicate that theanterior pituitary gland can be a target of Cr VI toxicity in vivo and in vitro, thus producing a negative impact on the hypothalamic–pituitary–gonadal axis and affecting the normal endocrine function