IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Comparison of nitrosative stress and apoptosis in non-anemic healthy rats after intravenous ferumoxytol, iron isomaltoside 1000, iron dextran, iron sucrose, and ferric carboxymaltose administration
Autor/es:
TOBLLI JE; CAO G; GIANI JF; DOMINICI FP; ANGEROSA M
Revista:
ARZNEIMITTEL FORSCHUNG DRUG RESEARCH
Editorial:
ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN
Referencias:
Año: 2014 vol. 64 p. 1 - 7
ISSN:
0004-4172
Resumen:
Iron is involved in the formation as well as in the scavenging of reactive oxygen and nitrogen species. Thus, iron can induce as well as inhibit both oxidative and nitrosative stress. It also has a key role in reactive oxygen and nitrogen species mediated apoptosis. We assessed the differences in tyrosine nitration and caspase 3 expression in the liver, heart, and kidneys of rats treated weekly with intravenous ferumoxytol, iron isomaltoside 1000, iron dextran, iron sucrose and ferric carboxymaltose (40 mg iron/kg body weight) for five weeks. Nitrotyrosine was quantified in tissue homogenates by Western blotting and the distribution of nitrotyrosine and caspase 3 was assessed in tissue sections by immunohistochemistry. Nitrotyrosine and caspase 3 levels were significantly (p
