Photophysics and photobiology of novel liposomal formulations of 2,9(10),16-(17),23(24)- tetrakis[(2-dimethylamino)ethyl-sulfanyl]phthalocyaninatozinc(II)

NOELIA C. LÓPEZ ZEBALLOS A, JULIETA MARINO B, MARÍA C. GARCÍA VIOR C, NICOLÁS CHIARANTE B, LEONOR P. ROGUIN B, JOSEFINA AWRUCH C,*, LELIA E. DICELIO A

DYES AND PIGMENTS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2013 vol. 96 p. 625 - 635

0143-7208

a b s t r a c tSix novel liposomal formulations of 2,9(10),16(17),23(24)-tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (Pc9) were investigated to establish how the environments affect their photophysicaland photobiological properties. The incorporation efficiency and solubility during a time periodwere evaluated. All Pc9-liposomal formulations were efficient singlet oxygen quantum yield generators.The photobiological potentials were evaluated on human nasopharynx KB carcinoma cells. None ofthe formulations studied showed cytotoxic effects in the absence of light, whereas all of them showedgood performance after irradiation. The 50% inhibition of cell proliferation (IC50) was in the range of0.21e0.47 mM for Pc9-loaded liposome formulations. A lysosomal localization was found for S-PEG aswell as for S.