IQUIFIB   02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Cytokines mediating inflemmation in a model of secondary immunodeficiency in Wistar rats: immunomodulation triggered by thymomodulin
Autor/es:
OLMOS S, BLOIS S, FRECHA C, MARQUEZ G, ROUX ME
Revista:
Europen Journal of Inflammation
Editorial:
Biolife s.a.s.
Referencias:
Lugar: Italia; Año: 2006 vol. 4 p. 97 - 107
ISSN:
1721-727X
Resumen:
We have previously demonstrated in a rat model of immunodeficiency, an increase in the number of ãä T cells in the gut lamina propria and in the number of CD8áá+, CD25+, ãä+ subpopulation of intestinal intraepithelial lymphocytes (iIEL). The increased percentage of CD8áá+ iIEL that express CD25 indicates inflammation. The present study confirms the existence of an inflammatory process in the immunodeficient animals (R21) that is not detectable at the histological level but is characterized by an increase of the pro-inflammatory cytokines TNF-á and INF-ã. We have shown a direct relationship between TNF receptor II (TNF-RII) expression and the higher level of the ãä+ iIEL expressing TNF-á (TCR ãä+/TNF-á+ cells) that could be indicating a differential T cell reactivity. The effect of the increased expression of inflammatory cytokines such as TNF-á and INF-ã sem. To be down regulated by the high level of antigens specific TGF-â expression, which, we believe, is antigen specific and appears to maintain oral tolerance. Finally, in malnourished animals NF-êB remains principally in the cytosol and is unable to translocate to the nucleus, indicating the existence of alterations in the metabolic pathways leading to nuclear factor êB translocation from the cytoplasm to the nucleus. The therapeutic action of the immunomodulator TmB was demonstrated by its capacity to return all the cytokines studied to control levels. Moreover, its effects allowed the transcription factor NF-êB to translocate to the nucleus from the cytosol.