IQUIFIB 02644
INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Unidad Ejecutora - UE
artículos
Título:
Synthesis and comparative photodynamic properties of two isosteric alkyl substituted zinc(II) phthalocyanines
Autor/es:
GABRIELA A. GAUNA, JULIETA MARINOB,1, MARÍA C. GARCÍA VIORA, LEONOR P. ROGUINB, JOSEFINA AWRUCHA,*
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Lugar: Paris; Año: 2011 vol. 46 p. 5532 - 5539
ISSN:
0223-5234
Resumen:
The synthesis and photophysical parameters of two novel isosteric cationic zinc(II) phthalocyanines:2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammoniumethylsulfanyl]phthalocyaninatozinc(II) tetraiodide(6) and 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N-methylammonium)ethoxy]phthalocyaninatozinc(II)tetraiodide (7) were investigated. Maximum absorption values were 686.5 nm and 678 nm for 6 and 7,respectively,whereas singletmolecular oxygen generationwas 0.42 and 0.67, respectively. The photodynamiceffect and the cellular uptake of both phthalocyanines were evaluated on human nasopharynx KB carcinomacells. After light exposure, phthalocyanine 6 showed a higher cytotoxic activity than 7. In addition, a higherintracellular uptake of 6 and a preferential localization within lysosomeswere demonstrated. The productionof a greater amount of reactive oxygen species after phthalocyanine 6 irradiationwould be responsible for itspotent phototoxic action on KB cells.
