Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling

MIQUET, JOHANNA G.; DÍAZ, MARÍA E.; DOMINICI, FERNANDO P.; GONZÁLEZ, LORENA; SOTELO, ANA I.

TRENDS IN ENDOCRINOLOGY AND METABOLISM

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 2021 vol. 32 p. 403 - 414

1043-2760

Epidermal growth factor receptor (EGFR) signaling has a central role in the re-generative response of the liver upon injury and is involved in cellular transforma-tion linked to chronic damage. Hepatic EGFR expression, trafficking, andsignaling are regulated by growth hormone (GH). Chronically elevated GH levelsare associated with liver cancer development and progression in mice. Studies indifferentin vivoexperimental models indicate that EGF and GH mutuallycrossregulate in a complex manner. Several factors, such as the extent of expo-sure to supraphysiological GH levels and the pattern of GH administration, areimportant variables to be considered in exploring the interplay between the twohormones in connection with the progression of hepatic tumors.