Stress oxidative and genotoxicity in Prochilodus lineatus (Valenciennes, 1836) exposed to commercial formulation of insecticide cypermethrin

C. E. DAVICOA, A. LOTESTEA,B, M. J. PARMAB,C, G. POLETTAA,C AND M. F. SIMONIELLOA

DRUG AND CHEMICAL TOXICOLOGY

TAYLOR & FRANCIS INC

Lugar: Londres; Año: 2018

0148-0545

The use of toxic pesticides has become a world problem because they can contaminate streams and rivers, producing an adverse impact on non-target aquatic biota, including fishes. Cypermethrin is one of the most important insecticides to control ectoparasites in wide-scale. The aim of this study was to evaluate the effect of commercial formulations of cypermethrin, SHERPA O (0.0, 0.075, 0.15, and 0.3 mg/L of cypermethrin) in fish Prochilodus lineatus for 96 h in semi-static condition, using biomarkers of genotoxicity:micronucleus frequency (MNF) in erythrocytes and biomarkers of oxidative damage: lipid peroxidation (TBARS) and antioxidant defenses, catalase (CAT) and glutathione (GSH) in liver tissue. Our results showed a significant decrease (p0.05) in comparison to the control. A significant increase was observed in the MNF in the group exposed to 0.3 lg/L of cypermethrin compared to negative control (p