INALI   02622
INSTITUTO NACIONAL DE LIMNOLOGIA
Unidad Ejecutora - UE
artículos
Título:
Evaluación de estrés oxidativo en pacientes con Lupus Eritematoso Sistémico y su posible relación con la exposición ambiental a agroquímicos
Autor/es:
MASTANDREA, CARLOS; PAIRA, SERGIO; BENABENTE EMILIO; POLETTA, GISELA L.; MARTINEZ, LEONARDO N.; ROVERANO, SUSANA; SIMONIELLO, MA. FERNANDA
Revista:
ACTA TOXICOLóGICA ARGENTINA
Editorial:
ASOCIACIÓN TOXICOLÓGICA ARGENTINA
Referencias:
Año: 2016 vol. 24 p. 10 - 20
ISSN:
0327-9286
Resumen:
The agrochemicals are an effective method to control harmful species of interests to humans, but when they are appliedindiscriminately, they can cause environmental and health damage to people. Systemic Lupus Erythematosus (SLE) is an autoimmunedisease that has a wide range of clinical manifestations and severity. While the etiology of SLE is unknown, it is associatedwith various environmental causes, being one possibility the exposure to agrochemicals. The aim of this study was to evaluate thepossible oxidative damage generated by environmental exposure to agrochemical mixtures in SLE patients and healthy peopleliving in rural areas and compare them with patients and healthy people living in urban, unexposed areas. Forty four patients diagnosedwith SLE and 58 healthy individuals (controls) were evaluated, using the following markers: Catalase (CAT), superoxidedismutase (SOD), the oxidized/reduced glutathione ratio (GSH / GSSG) and lipid peroxidation (TBARS). Statistically signi‚cant differenceswere found in TBARS and SOD by comparing the results of the urban SLE group with its control and rural SLE group withits control (p <0.01 for both cases). When making comparisons between urban SLE group and the rural SLE group, an increaseof 18.3% was found in TBARS (p = 0.014). This research demonstrates the importance of using biomarkers of oxidative stress inthe clinical monitoring of patients with SLE, in order to establish guidelines for appropriate treatment and consider the relationshipbetween environmental exposure to pesticides and increased oxidative damage in patients with SLE