INVESTIGADORES
SOLOVEY Guillermo
artículos
Título:
Observable effects of Ca2+ buffers on local Ca2+ signals
Autor/es:
G SOLOVEY; S P DAWSON
Revista:
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
Editorial:
ROYAL SOC
Referencias:
Lugar: Londres; Año: 2010 p. 5597 - 5603
ISSN:
1364-503X
Resumen:
Calcium signals participate in a large variety of physiological processes. In many instances, they involve calcium entry through inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs), which are usually organized in clusters. Recent high-resolution optical experiments by Smith & Parker have provided new information on Ca2+ release from clustered IP3Rs. In the present paper, we use the model recently introduced by Solovey & Ponce Dawson to determine how the distribution of the number of IP3Rs that become open during a localized release event may change by the presence of Ca2+ buffers, substances that react with Ca2+, altering its concentration and transport properties. We then discuss how buffer properties could be extracted from the observation of local signals.