INVESTIGADORES
FRAIMAN BORRAZAS Daniel Edmundo
artículos
Título:
Stochastic fire-diffuse-fire model with realistic cluster dynamics
Autor/es:
ANA CALABRESE; DANIEL FRAIMAN; DANIEL ZYSMAN; SILVINA PONCE DAWSON
Revista:
PHYSICAL REVIEW E - STATISTICAL PHYSICS, PLASMAS, FLUIDS AND RELATED INTERDISCIPLINARY TOPICS
Editorial:
American Physical Society
Referencias:
Año: 2010 vol. 82 p. 31910 - 31921
ISSN:
1063-651X
Resumen:
Living organisms use waves that propagate through excitable media to transport information. Ca2+ waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2+ signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In these cells, Ca2+ release occurs trough inositol 1,4,5-trisphosphate receptors (IP3Rs) which are organized in clusters of channels located on the membrane of the endoplasmic reticulum. In this article we construct a stochastic model for a cluster of IP3R’s that replicates the experimental observations reported in [D. Fraiman et al., Biophys. J. 90, 3897 (2006)]. We then couple this phenomenological cluster model with a reaction-diffusion equation, so as to have a discrete stochastic model for calcium dynamics. The model we propose describes the transition regimes between isolated release and steadily propagating waves as the IP3 concentration is increased.