IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
ANALYSIS OF PIN1 EXPRESSION AND FUNCTION DURING ZEBRAFISH DEVELOPMENT REVEALS A DYNAMIC REGULATION
Autor/es:
IBARRA S; GIRARDINI J.E.; MIONE M.; MARGARIT E
Lugar:
Mar del Plata
Reunión:
Congreso; LXI REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC); 2016
Resumen:
ANALYSIS OF PIN1 EXPRESSION AND FUNCTION DURING ZEBRAFISH DEVELOPMENT REVEALS A DYNAMIC REGULATION Solange Ibarra1, Ezequiel argarit2, Marina Mione3, Javier Girardini1. Instituto de Biología Molecular y Celular de Rosario. 2Centro de Estudios Fotosintéticos y Bioquímicos. 3Centre For Integrative Biology - CIBIO, University Of Trento.The prolyl isomerase in plays a ey role in the modulation of prolinedirected phosphorylation signaling by inducing local conformational changes in phosphorylated protein substrates. esides being involved in physiological processes, a large body of evidences has shon that in may affect pathological conditions. For example, clinical studies have shon that in is frequently overexpressed in different cancers and in some cases its overexpression correlates ith clinical outcome. Also, its deregulation has been related to brain disorders, including Alzheimers, arinsons and Huntingtons disease. espite several evidences on the effect of in on specific substrates or signaling pathays, there are still several unansered questions regarding its biological role and, particularly, little is non about its regulation. otably, the current evidences shoing that in expression and activity may be regulated by different mechanisms ere generated only on cultured cells, and there is almost no evidence of its relevance in vivo. Considering the dependence of in on the particular combination of protein substrates present in a specific cell type and on the activation of signaling pathays able to phosphorylate its binding sites, studies in animal models may provide novel insights, useful to understand prolinedirected phosphorylation signaling and the consequences of in deregulation. sing anio rerio zebrafish as a vertebrate model organism, e shoed that pin expression is regulated during embryogenesis to achieve specific mA and protein distribution patterns. oreover, e found that in overexpression affected specific regions of the developing embryos and e extended the study of in expression to the adult zebrafish brain. ur results suggest that specific mechanisms are operated in different cell types to regulate in function.