IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
BEHAVIORAL EFFECTS OF THE MODIFICATION OF FATTY ACID METABOLISM IN Caenorhabditis elegans
Autor/es:
GALLES. C.; DE MENDOZA, D.
Lugar:
Mar del Plata
Reunión:
Congreso; LI Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; 2015
Institución organizadora:
SAIB
Resumen:
Downregulation of the expression of long chain fatty acid metabolism enzymes LET-767, ELO-5 and SPTL-1 by the RNA interference approach leads to an increase in the aversion behavior of wild-type Caenorhabditis elegans N2 nematodes towards the normally palatable food Escherichia coli HT115. Rescue of this aversion phenotype by supplementation with different lipids such as arachidonic acid and its endocannabinoid derivatives is carried out, together with treatment with monoacylglycerol lipase inhibitor JZL 184. Finally, study of the aversion behavior of fatty acid metabolism mutant nematodes fat-3(ok1126) and elo-5(gk208) is assayed, raising the possibility of a communication between different lipid metabolism pathways, known to regulate postembryonic development and behavior. These observations suggest the existence of a neuroendocrine signal linking lipid metabolism in the intestine with the neurons that modulate behavior and development in Caenorhabditis elegans.