MOLECULAR EPIDEMIOLOGY OF HPV IN HEALTHY SKIN FROM IMMUNOSUPPRESSED AND IMMUNOCOMPETENT INDIVIDUALS

ADRIANA SÁNCHEZ; RAMÓN FERNANDEZ BUSSY JR.; JESICA NIPOTI; GUSTAVO PICCIRILLI; ELISA BOLATTI; DIEGO CHOUHY; PABLO CASAL; EMMA J. STELLA; ADRIANA A. GIRI; RAMÓN FERNANDEZ BUSSY

Vancouver

Congreso; XXIII World Congress of Dermatology; 2015

International League of Dermatological Societies

Papillomaviruses (PVs) are DNA tumour viruses infecting mucosal and cutaneous epithelia of vertebrates. More than 190 human PVs (HPVs) types have been completely sequenced. Although the clinical implications of the cutaneous HPV types are still unknown, it has been proposed that immunosuppression (UV + immunosuppressive treatment) may contribute to HPV infection. In order to explore the diversity of cutaneous HPVs on healthy skin from individuals with different immunological status, we designed a transversal descriptive study including 100 immunocompetent (IC) and 64 immunosuppressed (IS) individuals. Skin samples were collected from the forehead using a non-invasive procedure and analyzed by hanging droplet PCR with the FAP primer system. HPV DNA was more frequently found in the IC group (65% IC vs. 56% IS). In both populations, the majority of HPV types and putative types identified belonged to the Beta- and Gama-PV genera, being HPV-20 (Beta-1) the most prevalent type. Time of sun exposure and age were significantly higher (p