IBR   13079
INSTITUTO DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
REGULATION OF LIPID BIOSYNTHESIS IN GRAM-POSITIVE BACTERIA
Autor/es:
CROTTA ASIS, AGOSTINA; MACHINANDIARENA, FEDERICO; DE MENDOZA, DIEGO; ALBANESI, DANIELA
Lugar:
Rosario
Reunión:
Congreso; L Reunión Anual Sociedad Argentina de Investigación en Bioquímica y Biología Molecular; 2014
Institución organizadora:
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Resumen:
A crucial but often overlooked aspect of cell biogenesis and survival is the need for precise coordination between the biosynthesis of its macromolecular constituents. In the case of bacterial cells, this means producing appropriate amounts of four classes of macromolecules: nucleic acids, proteins, lipids and the polysaccharides of the cell wall. The molecular basis of coordination is well known in some cases. In others it is still rather misterious. In this work we combine fisiological and biochemical strategies to study, in the model Gram-positive bacteria Bacillus subtilis: i) the role of the signaling nucleotide ppGpp in the two-way coordination between lipid synthesis and cell growth and ii) the transcriptional and activity regulation of acetyl-CoA carboxylase (ACC), a key enzyme of the lipid biosynthetic pathway. Our results pave the way to understanding how Gram-positive bacteria coordinate lipid and membrane synthesis with its other biosynthetic activities and in response to environmental conditions.