IIBBA   05544
INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE BUENOS AIRES
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Newly generated neurons convey higher levels of associativity to information processing in the adult dentate gyrus.
Autor/es:
MA. BELEN PARDI; LUCAS MONGIAT; ALEJANDRO F. SCHINDER; ANTONIA MARIN BURGIN
Lugar:
Cordoba
Reunión:
Congreso; II Reunion Conjunta en Neurociencias; 2010
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
Adult neurogenesis provides a constant pool of new granule cells (GCs) to the dentate gyrus (DG) of the hippocampus. During maturation, these GCs present higher excitability than mature neurons and require weaker inputs to be recruited in response to activation of afferent inputs. These properties suggest that while mature GCs are presumably more selective in their responses, immature GCs could be recruited by several inputs, allowing associations to occur. To study differences in associativity between mature and immature GCs, we combined imaging and electrophysiological recordings from hippocampal slices obtained from adult mice after retroviral expression of RFP to identify immature GCs. GCs activity was monitored by loading the cells with a calcium dye. Two electrodes were placed to stimulate independent medial perforant path inputs at different intensities. The results showed that immature GCs presented higher levels of associativity than mature GCs, and that these levels were independent of inhibition in immature neurons, yet incremented by blockade of inhibition with picrotoxin in mature neurons. The increased associativity observed in immature GCs suggests that this population of neurons could serve the DG to produce temporal associations.